Cancer cells cumulate genetic and epigenetic changes (mutations, polyploidisations) during carcinogenesis and cancer progression. These alterations fuel the adaptation of cells to the diversity of micro-environmental constraints that they face all along the growth of tumors. The evolution of tumors generates, among others, angiogenesis, metastasis and post-therapeutic recurrence.
It is thus crucial to understand the mechanisms of cancer evolution, in order to limit its progression and to develop novel therapeutic approaches.
Notably, the accumulation of alterations should lead to selection waves that limit genetic and phenotypic diversity within each tumor. However, intratumor heterogeneity increases during tumor progression. Thus, we propose to study the role of interactions between cancer cells into the generation and the maintenance of clonal diversity within tumors.